The colloquium will be streamed online.
Prof. Akihiro Kusumi, Okinawa Institute of Science and Technology Graduate University (OIST)
Invited by Prof. Claudia Veigel and Prof. Petra Schwille
First, I will talk about the world’s fastest single-molecule imaging and PALM/dSTORM we developed (0.1-ms time resolution with 29-nm localization precision for single-molecule imaging and PALM/dSTORM images obtained in 10 s). Second, I will present our finding of a 34-nm-diameter liquid-like signaling platform on the plasma membrane, termed iTRVZ, formed via zyxin’s intrinsically disorderd region (IDR) on the surfaces of raft domains and actin membrane skeleton. We found that iTRVZ is responsible for integrating the signals downstream from very different receptors: PDGF receptor, which induces cell proliferation, and CD59, a GPI-anchored receptor responsible for cellular immune evasion. In mice, iTRVZ promotes tumor growth by enhancing the CD59 and PDGF receptor signals.