The colloquium will be streamed online.
Prof. Possu Huang, Stanford University
Invited by Prof. Alena Khmelinskaia and Prof. Lukas Milles
Developing highly specific binding proteins is fundamental to theragnostics. We develop general systems, called TRACeRs, to target the major histocompatibility complex (MHC) antigens. TRACeRs have unique peptide-focused targeting mechanisms for MHCs with unprecedented specificity and multi-allotype compatibility. Beyond strategies to address the molecular targeting problem, we develop next-generation protein generative models to capture conformational flexibility towards custom-made function. Our generative design algorithms, Protpardelle and Sculptor, are used to build novel protein functions, from de novo GPCR agonists to lanthanide binding proteins. I will describe these exciting new efforts in protein design.